HuagongsheHuagongshe Chemistry Print Report · For research reference only
Gadolinium → Gadobutrol (JAN/USAN/INN)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Gadolinium | HCID 23982 | — |
| Reactant | 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt | HCID 10862527 | — |
| Reactant | 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane | HCID 11094747 | — |
| Product | Gadobutrol (JAN/USAN/INN) | HCID 15814656 | — |
Reaction Steps
The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 448191, with 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane to give the alkylated product, which can, easily be complexed with gadolinium to give the final Gadobutrol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162912 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-b5ea5c9070954433ba820550abe7823e |
| Source note | uspto-grants-2000_12 |