Trimethyl orthoformate → 3-Bromo-4-chlorobenzaldehyde dimethyl acetal

HRID 1275840Notes

Reaction equation

HRID 1275840 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])C=O.[CH:11](OC)([O:14][CH3:15])[O:12][CH3:13]>>[CH3:13][O:12][CH:11]([O:14][CH3:15])[C:4]1[CH:7]=[CH:8][C:9]([Cl:10])=[C:2]([Br:1])[CH:3]=1

Participants

3

Reactant 2

HCID 9005Trimethyl orthoformateHCID 140498093-Bromo-4-chlorobenzaldehyde

Product 1

HCID 153006433-Bromo-4-chlorobenzaldehyde dimethyl acetal

Procedure

A solution of 6.8 g of 3-bromo-4-chlorobenzaldehyde in 17 ml of trimethyl orthoformate was stirred with 6.9 g of Amberlyst 15 resin at room temperature overnight. The mixture was filtered and the filtrate was evaporated to give 4.5 g of 3-bromo-4-chlorobenzaldehyde dimethyl acetal as a colourless oil, mass spectrum (EI) m/e 266 [M+].

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-484f1940086741c78be2f6b57d33922f
Source dataset
uspto-grants-2000_12
Patent number
US06162918

Reaction notes

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