反应详情

The product from example 8(0.4 g) was dissolved in dry dimethylformamide (15 ml) and treated with N,N-carbonyldiimidazole (0.16 g). After 30 minutes L-aspartic acid dimethyl ester (0.32 g) was added followed by triethylamine (0.5 ml). The mixture was stirred overnight and partitioned between ethyl acetate and 2M HCl. The organic phase was washed with brine, dried (MgSO4), evaporated and purified by chromatography eluting with 50% ethyl acetate in dichloromethane. Used directly in the next step.

1. custompartitioned between ethyl acetate and 2M HCl
2. washThe organic phase was washed with brine
3. dry with materialdried (MgSO4)
4. customevaporated
5. custompurified by chromatography
6. washeluting with 50% ethyl acetate in dichloromethane