Diisopropylethylamine → HCID 131722228, compound

Participants

Reaction Steps

A mixture of the product of step (ii) (0.22 g), product of example 11(0.2 g), bromo-tris(pyrrolidino)-phosphonium hexafluorophosphate (0.24 g), 4-dimethylaminopyridine (0.056 g) and N,N-diisopropylethylamine (0.2 ml) in dimethylformamide (5 ml) was stirred at room temperature for 24 hours. The mixture was partitioned between ethyl acetate and brine, washed with saturated aqueous sodium bicarbonate, dilute HCl and brine, dried (MgSO4) and evaporated. Purification was by chromatography eluting with ethyl acetate. Yield 0.24 g.

Provenance & Evidence