Methyl iodide → HCID 22117250, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from step (i) (9.5 g) in tetrahydrofuran (40ml) at -60° C. was added n-butyllithium (17 ml of a 2.5M solution in hexanes) dropwise. The mixture was stirred at -65° C. for 1 hour and methyl iodide (12 ml) was added. The mixture was stirred at room temperature for 1 hour and quenched with brine. The organic phase was dried (MgSO4) and evaporated. Yield 9.56 g. Used directly in the next step.

Provenance & Evidence