Dimethylamine → HCID 21999572, compound

HRID 1275930Notes

Reaction equation

HRID 1275930 reaction equation
[F:1][C:2]1[CH:7]=[C:6](F)[C:5]([F:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[CH3:13][NH:14][CH3:15]>C(O)C>[CH3:13][N:14]([CH3:15])[C:6]1[C:5]([F:9])=[CH:4][C:3]([N+:10]([O-:12])=[O:11])=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 750121,2,4-Trifluoro-5-nitrobenzene

Product 1

HCID 21999572HCID 21999572, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 2,4,5-trifluoronitrobenzene (8.9 g, 50 mmol) in 100 mL ethanol is bubbled dimethylamine gas (6.8 g, 150 mmol). The solution is heated at 80° C. in a Parr pressure reactor for 6 hours. After evaporation of the solvent the product is chromatographed on silica gel/methylene chloride to give Compound 18.

Workup

  1. customAfter evaporation of the solvent the product
  2. customis chromatographed on silica gel/methylene chloride

Sources & evidence

ORD record
ord-dcc6acf4baf24bd0a18b10bd9e7c1ed8
Source dataset
uspto-grants-2000_12
Patent number
US06162931

Reaction notes

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