Water → HCID 21999537, compound

Participants

Reaction Steps

2,4-Difluororesorcinol (13, 0.200 g, 1.37 mmol) and 2-sulfoterephthalic acid (0.184 g, 0.68 mmol) are heated together in methanesulfonic acid (2 mL) at 100° C. overnight with stirring. After cooling, the reaction mixture is poured into cold water (30 mL). Sodium chloride is added portionwise with stirring until a precipitate forms, which is collected on a Buichner finnel and dried in vacuo to give Compound 83 as 40 mg of a red-orange powder: Rf =0.65 (CH3CN:H2O:acetic acid 8:1:1).

Provenance & Evidence