Bromoacetyl bromide → n-Butyl-n-propoxy-bromoacetamide

Participants

Reaction Conditions

Reaction Steps

The salt of Example 538B (0.60 g) was dissolved in acetonitrile (5 mL) and cooled to -20° C. Hunig's base (5.5 mL) was added slowly. Bromoacetyl bromide (0.5 mL) was added dropwise over five minutes. The solution was stirred at -20° C. for 30 minutes. The bath was removed and the solution was stirred for six hours at room temperature. The solvent was removed in vacuo and the residue taken up in EtOAc (50 mL) and washed with water (1×25 mL), 1N phosphoric acid (3×25 mL), and brine (1×25 mL). The organic layer was dried with sodium sulfate and evaporated to give a dark orange oil (0.65 g) which was used without further purification.

Provenance & Evidence