Hydrochloric Acid → HCID 22114771, compound

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Reaction Steps

3-(m-Nitrobenzyloxy)acridine-9-carboxylic acid methylester (6.5 g; 16.7 mmol) was refluxed in 400 ml dioxane and 300 ml NaOH 1N. After 2 hours the solution was cooled and acidified to pH 1 with HCl conc., then evaporated in vacuo. The precipitate was collected on a Buchner funnel, washed with water and dried in vacuo at 50° C. Yield 5.9 g (95%), Fp.>250° C. 1H-NMR(DMSO-d6): 8.44(1H, s, ar.); 8.23(1H, d, ar.); 8.10(2H, t, ar.); 8.03(1H, d, ar.); 7.95(1H, d, ar.); 7.72(2H. m, ar.); 7.42(2H, m, ar.); 7.27(1H, d, ar.); and 5.50 ppm (2H, s, CH2). MS: M+ =374.

Provenance & Evidence