2,2-Diethoxyethylamine → HCID 22114886, compound

HRID 1276054Notes

Reaction equation

HRID 1276054 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[C:9]2SC)=[C:4]([F:21])[CH:3]=1.[CH2:22]([O:24][CH:25]([O:28][CH2:29]C)[CH2:26][NH2:27])C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[C:9]2[NH:27][CH2:26][CH:25]([O:28][CH3:29])[O:24][CH3:22])=[C:4]([F:21])[CH:3]=1

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 22114873HCID 22114873, compound

Product 1

HCID 22114886HCID 22114886, compound

Procedure

3-(4-Bromo-2-fluorophenyl)-3,4-dihydro-2-methylthio-6-trifluoromethylpyrimidin-4-one (21.5 g) and aminoacetaldehyde diethyl acetal (15 g) were stirred for 3 hours at 130° C. The excess aminoacetaldehyde diethyl acetal was distilled off under reduced pressure and the residue was used in the next reaction as it was.

Workup

  1. distillationThe excess aminoacetaldehyde diethyl acetal was distilled off under reduced pressure
  2. customthe residue was used in the next reaction as it

Sources & evidence

ORD record
ord-eb4da2ffcdc046b99ac3ab4f5fb60c05
Source dataset
uspto-grants-2000_12
Patent number
US06165942

Reaction notes

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