Nitric Acid → HCID 22114877, compound

HRID 1276056Notes

Reaction equation

HRID 1276056 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]3[CH:19]=[CH:20][N:21]=[C:9]23)=[C:4]([F:22])[CH:3]=1.[N+:23]([O-])([OH:25])=[O:24]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:7]([N+:23]([O-:25])=[O:24])=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:17])([F:18])[F:16])[N:10]3[CH:19]=[CH:20][N:21]=[C:9]23)=[C:4]([F:22])[CH:3]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 22114872HCID 22114872, compound

Product 1

HCID 22114877HCID 22114877, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

8-(4-Bromo-2-fluorophenyl)-7,8-dihydro-5-trifluoromethylimidazo[1,2-a]pyrimidin-7-one (12 g) was dissolved into concentrated sulfuric acid (50 ml) to which then nitric acid (60%, d=1.38; 5.0 g) was added under ice-cooled condition, and stirred for 2 hours at room temperature. The reaction solution was poured into ice water and the thus obtained solid was filtered off. The solid was washed with water and dried to give the compound of interest (12.5 g).

Workup

  1. temperaturecooled condition
  2. filtrationthe thus obtained solid was filtered off
  3. washThe solid was washed with water
  4. customdried
  5. customto give the compound of interest (12.5 g)

Sources & evidence

ORD record
ord-3e7ad7617fa449c6ae7c7f5a216977eb
Source dataset
uspto-grants-2000_12
Patent number
US06165942

Reaction notes

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