Dimethylformamide → HCID 57182539, compound

Participants

Reaction Conditions

Reaction Steps

8-(2-Fluoro-4-hydroxyphenyl)-7,8-dihydro-5-trifluoromethylimidazo[1,2-a]pyrimidin-7-one (200 mg) was dissolved into DMF (6 ml), which was then added with potassium carbonate (106 mg) and methyl 2-(2-(chloromethyl)-5-methylphenoxy)propanoate (155 mg), and stirred for 2 hours at 75° C. Subsequently, the mixture was added with water and extracted with diethyl ether. The organic layer was dried on magnesium sulfate followed by distilling off the solvent under reduced pressure. The thus obtained residue was purified by a preparative thin-layer plate of silica gel (developing solvent: ethyl acetate/hexane=2/3) to give the compound of interest (170 mg).

Provenance & Evidence