反应详情

温度

2.5 °C

40.8 g of 100% nitric acid were added dropwise at from 0 to 5° C. to a solution of 118.9 g of 3-chloro-2-(4-fluorophenyl)-5-trifluoromethylpyridine in 563 ml of 96% sulfuric acid, and the mixture was then stirred at from 0 to 5° C. for 11/2 hours. For work-up, the reaction mixture was poured into 2 l of ice water, and the product was then extracted with ethyl acetate (3×300 ml). The combined organic phases were washed twice with 100 ml of water in each case, dried over sodium sulfate and then evaporated. Yield: 134.5 g (97%) of a colorless oil which crystallized slowly.

1. extractionthe product was then extracted with ethyl acetate (3×300 ml)
2. washThe combined organic phases were washed twice with 100 ml of water in each case
3. dry with materialdried over sodium sulfate
4. customevaporated
5. customYield: 134.5 g (97%) of a colorless oil which crystallized slowly