HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2-[4-(1-methylethylamino)-3-nitrophenyl]-5-trifluoromethylpyridine → 2-[3-Amino-4-(1-methylethylamino)phenyl]-3-chloro-5-trifluoromethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2-[4-(1-methylethylamino)-3-nitrophenyl]-5-trifluoromethylpyridine | HCID 22114839 | — |
| Reactant | 2-Amino-4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]benzenol | HCID 135549970 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | 2-[3-Amino-4-(1-methylethylamino)phenyl]-3-chloro-5-trifluoromethylpyridine | HCID 22114841 | 93% |
Reaction Steps
In a similar manner to the preparation of 3-chloro-2-(3-amino-4-hydroxyphenyl)-5-trifluoromethylpyridine described above, 46.1 g of 3-chloro-2-[4-(1-methylethylamino)-3-nitro-phenyl]-5-trifluoromethylpyridine and 21.5 g of iron powder gave 39.1 g (93%) of colorless crystals; m.p.: 116-117° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06165941 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-37082797aeaf483f8bc329006fb6fe6e |
| Source note | uspto-grants-2000_12 |