Hydrochloric Acid → HCID 178439345, compound

Participants

Reaction Conditions

Reaction Steps

130 mg of guanidine hydrochloride and 125 mg of potassium t-butoxide are stirred at RT for 30 minutes in 1 ml of anhydrous DMF. A solution of 150 mg of ethyl 3-(4-{2-[17-(3-carboxy-1-methylpropyl)-7,12-dihydroxy-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-3-yloxy]ethylamino}-3,5 -difluorophenyl)-2-methylacrylate in 1 ml of anhydrous DMF is then added and the mixture is stirred at 110-115° C. for 6 hours. The reaction mixture is then poured onto 100 ml of water, adjusted to pH=6 using aqueous HCl solution and the product is filtered off. It is dried in a fine vacuum and 8.0 mg of an amorphous solid are obtained. Rf (CH2C12 /MeOH/acetic acid/water 32:8:1:1)=0.21 MS (ES): 689 (M+H)+

Provenance & Evidence