Sodium Hydroxide → HCID 22114933, compound

Participants

Reaction Steps

A solution of 5.82 g (15 mmol) of methyl 2-chloro-3-(1-chloro-2,2-dimethyleth-2-ylaminocarbonyl)-4-methylsulfonylbenzoate and 0.81 g (20 mmol) of sodium hydroxide in 80 ml of methanol was stirred at room temperature for 8 hours. The solvent was distilled off and the residue was taken up in water and washed three times with ethyl acetate. The aqueous phase was acidified with hydrochloric acid and extracted three times with ethyl acetate. The organic phase was dried and the solvent was removed under reduced pressure. 3.10 g (56% of theory) of 2-chloro-3-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-4-methylsulfonylbenzoic acid were obtained.

Provenance & Evidence