(2S)-1-(1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid → (2S)-1-(1,3-benzoxazol-2-yl)-N2-[2-(3,5-dimethylmorpholino)ethyl]-2-piperidinecarboxamide

Participants

Reaction Steps

The title compound was prepared by a similar method to Example 1 from (2S)-1-(1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid [see Preparation 3] and 2-(3,5-dimethylmorpholino)ethylamine [see Preparation 12]. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 100:0 changing to 95:5, by volume dichloromethane:methanol to afford (2S)-1-(1,3-benzoxazol-2-yl)-N2 -[2-(3,5-dimethylmorpholino)ethyl]-2-piperidinecarboxamide as a solid.

Provenance & Evidence