HCID 22115615, compound → HCID 22115590, compound

HRID 1276193Notes

Reaction equation

HRID 1276193 reaction equation
C([O:8][C:9]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[C:14]([N:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)[CH:15]=[CH:16][CH:17]=2)[CH:12]=1)=[O:10])C1C=CC=CC=1>C(O)C>[CH3:27][N:24]1[CH2:25][CH2:26][N:21]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:13]=2[CH:12]=[C:11]([C:9]([OH:10])=[O:8])[CH:20]=[CH:19]3)[CH2:22][CH2:23]1

Participants

3

Reactant 1

HCID 22115615HCID 22115615, compound

Product 1

HCID 22115590HCID 22115590, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture of 8-(4-methylpiperazin-1-yl)naphthalene-2-carboxylic acid benzyl ester (0.20 g, 5.55 mmol) and Pd(OH) on carbon (0.11 g) in 2 mL of ethanol was hydrogenated on a Parr shaker apparatus at 50 psi for 5 hr. After diluting with ethanol and filtering through diatomaceous earth, the solvent was removed in vacuo to yield the title product as a foam, 138 mg.

Workup

  1. filtrationfiltering through diatomaceous earth
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1d7c77488ef847378da6019926e1f97b
Source dataset
uspto-grants-2000_12
Patent number
US06166020

Reaction notes

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