HCID 22115821, compound → HCID 178480075, compound

Participants

Reaction Conditions

Reaction Steps

2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamine hydrochloride (34.66 g) in 95% ethanol (600 ml) was warmed to 65° C. to dissolve most of the solids, and the mixture was then allowed to cool with stirring. The next day, the fine suspension of solids was treated with 2-thiophenecarboximidothioic acid, ethyl ester, hydrochloride (41 g) and stirred at 23° C. All solids had dissolved by 2 h, and by 4 h new solids had precipitated. The mixture was treated with concentrated hydrochloric acid (2 ml). The mixture was cooled to 0° C. and stirred for 30 minutes. The solids were filtered off, washed with ethanol (2×50 ml), and air dried to provide N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-thiophenecarboximidamide dihydrochloride, m.p. 142-146° C.; MS m /z 272 [M+H]+.

Provenance & Evidence