Sodium Methoxide → HCID 18416655, compound

HRID 1276206Notes

Reaction equation

HRID 1276206 reaction equation
[C:1]([NH:4][CH:5]([CH3:10])[CH:6]=[C:7](Cl)Cl)(=[O:3])[CH3:2].[CH3:11][O-:12].[Na+]>CO>[CH3:2][C:1]1[O:3][C:6]([CH2:7][O:12][CH3:11])=[C:5]([CH3:10])[N:4]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 18416647HCID 18416647, compound

Product 1

HCID 18416655HCID 18416655, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.8 g of 3-acetamido-1,1-dichlorobut-1-ene and 1,0 g of sodium methylate in 20 ml of methanol is heated at the boiling point under reflux for 24 hours. Thereafter, the methanol is distilled off, the residue is taken up in 5 ml of water and 30 ml of methylene chloride and the organic phase is separated off and distilled in vacuo. 0.9 g of 2,4-dimethyl-5-methoxymethyl-oxazole is obtained, boiling point 54° C./20 mbar.

Workup

  1. temperatureunder reflux for 24 hours
  2. distillationThereafter, the methanol is distilled off
  3. custom30 ml of methylene chloride and the organic phase is separated off
  4. distillationdistilled in vacuo

Sources & evidence

ORD record
ord-d015e08dc9b34c72bd90348adea1208c
Source dataset
uspto-grants-2000_12
Patent number
US06166027

Reaction notes

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