N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2-chloro-6-fluorophenyl)-4-phenyl-5,6-dihydro(4H)1,3-oxazine

Participants

Reaction Steps

The procedure is as for Example 85, but 3.5 g (11.4 mmol) of N-(2-chloro-6-fluorobenzoyl)-3-amino-3-phenyl-1-propanol are employed instead of N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl)-1-propanol. 2.2 g (66.8%) of 2-(2-chloro-6-fluorophenyl)-4-phenyl-5,6-dihydro(4H)1,3-oxazine are obtained as a colorless oil.

Provenance & Evidence