N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2,6-difluorophenyl)-4-(3-trifluoromethylphenyl)-5,6-dihydro(4H)1,3-oxazine

Participants

Role	Name	HCID	Charge
Reactant	N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol	HCID 15790732	—
Reactant	N-(2,6-difluorobenzoyl)-3-amino-3-(3-trifluoromethylphenyl)-1-propanol	HCID 22115241	—
Product	2-(2,6-difluorophenyl)-4-(3-trifluoromethylphenyl)-5,6-dihydro(4H)1,3-oxazine	HCID 22115245	71.3%

Reaction Steps

The procedure is as for Example 85, but 4 g (11.1 mmol) of N-(2,6-difluorobenzoyl)-3-amino-3-(3-trifluoromethylphenyl)-1-propanol are employed instead of N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl)-1-propanol. 2.7 g (71.1%) of 2-(2,6-difluorophenyl)-4-(3-trifluoromethylphenyl)-5,6-dihydro(4H)1,3-oxazine are obtained as a colorless oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06166010
Source dataset	uspto-grants-2000_12
ORD ID	ord-0935128c2f924cf89b184eed286c6a9c
Source note	uspto-grants-2000_12