N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2,6-difluorophenyl)-4-(3-tert-butylphenyl)-5,6-dihydro(4H)1,3-oxazine

Participants

Reaction Steps

The procedure is as for Example 85, but 4.0 g (11.5 mmol) of N-(2,6-difluorobenzoyl)-3-amino-3-(3-tert-butylphenyl)-1-propanol are employed instead of N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol. 2.6 g (68.6%) of 2-(2,6-difluorophenyl)-4-(3-tert-butylphenyl)-5,6-dihydro(4H)1,3- oxazine are obtained as a colorless oil.

Provenance & Evidence