N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → HCID 22362151, compound

HRID 1276217Notes

Reaction equation

HRID 1276217 reaction equation
[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[C:4]([NH:6][CH:7]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:12]=1)[CH2:8][CH2:9]O)=[O:5].FC1C=CC=C(F)C=1C(NC(C1C=CC(Cl)=CC=1)CCO)=O>>[F:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:2]([F:1])[C:3]=1[C:4]1[O:5][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:12]=2)[N:6]=1

Participants

3

Reactant 2

HCID 15790732N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanolHCID 22362149HCID 22362149, compound

Product 1

HCID 22362151HCID 22362151, compound

Procedure

The procedure is as for Example 85, but 4.0 g (10.3 mmol) of N-(2,6-difluorobenzoyl)-3-amino-3- (3-n-heptylphenyl)-1-propanol are employed instead of N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl)-1-propanol. 2.7 g (70.8%) of 2-(2,6-difluorophenyl-4-(3-n-heptylphenyl)-5,6-dihydro(4H)1,3-oxazine are obtained as a colorless oil.

Sources & evidence

ORD record
ord-5530245e068e475ca73574ada53610bf
Source dataset
uspto-grants-2000_12
Patent number
US06166010

Reaction notes

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