N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2,6-difluorophenyl)-4-(3-methyl-4'-trifluoromethoxybiphenyl-4-yl)-5,6-dihydro(4H)1,3-oxazine

Participants

Reaction Steps

The procedure is as for Example 85, but 5.0 g (10.8 mmol) of N-(2,6-difluorobenzoyl)-3-amino-3-(3-methyl-4'-trifluoromethoxybiphenyl-4-yl)-1-propanol are employed instead of N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl)-1-propanol. 3.1 g (64.5%) of 2-(2,6-difluorophenyl)-4-(3-methyl-4'-trifluoromethoxybiphenyl-4-yl)-5,6-dihydro(4H)1,3-oxazine are obtained as a colorless oil.

Provenance & Evidence