Water → HCID 15790727, compound

Participants

Reaction Steps

2,6-Difluorobenzoyl chloride (2.65 g, 0.015 mol) is added in portions to a solution of 3-amino-3- (4-t-butylphenyl)-1-propanol (3.1 g, 0.015 mol) and triethylamine (3.03 g, 0.04 mol) in 30 ml of acetonitrile at room temperature (20° C.) in the course of 10 minutes. The reaction mixture is further stirred for 7 hours, water is added and the mixture is extracted with ethyl acetate. 4.5 g of N-[1-(4-t-butylphenyl)-3-hydroxy-propyl]-2,6-difluorobenzamide are isolated from the ethyl acetate phase as a crude product having a content of 28% according to GC/MS analysis, which is employed as such in the next reaction step.

Provenance & Evidence