HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 1-(4-Amino-2-chlorophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | [3-Chloro-4-(1-hydroxy-ethyl)-phenyl]carbamic acid 2-trimethylsilanyl-ethyl ester | HCID 54096646 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Amino-2-chlorophenyl)ethanol | HCID 18543601 | — |
Reaction Steps
A 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (5.7 mL) is added to [3-chloro-4-(1-hydroxy-ethyl)-phenyl]-carbamic acid 2-trimethylsilanyl-ethyl ester (0.5 g) and the mixture is stirred at room temperature for approximately 3.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06166028 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-2805f527839948d091d103a50d50cb87 |
| Source note | uspto-grants-2000_12 |