HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrole → 5-Chloro-1-(1H-pyrrol-2-yl)-1-pentanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrole | HCID 8027 | — |
| Reactant | 5-Chlorovaleryl chloride | HCID 74089 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 5-Chloro-1-(1H-pyrrol-2-yl)-1-pentanone | HCID 10103887 | — |
Reaction Steps
A solution of 26.7 g (0.200 mol) of aluminium chloride and 31 g (0.200 mol) of 5-chlorovaleryl chloride in 200 ml of 1,2-dichloroethane is added slowly to a solution of 13.4 g (0.200 mol) of pyrrole in 250 ml of 1,2-dichloroethane. The reaction medium is stirred for 2 h at room temperature and is poured onto ice-cold hydrochloric acid. After extraction with methylene chloride, a red-brown oil is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06166035 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-7ae910d74cad4b3badd23967fdaf577c |
| Source note | uspto-grants-2000_12 |