Sodium hydride → HCID 14422727, compound

Participants

Reaction Steps

To a solution of 1.5 g of (cyclopentyl)methanol in 50 ml of tetrahydrofuran is added 720 mg of 50% sodium hydride. After stirring until evolution of H2 is substantially complete (about 30 minutes), a solution of 4.5 g of crude 7-benzyloxy-4-bromo-3,4-dihydro-1-benzoxepin-5 (2H)-one is added. The reaction is allowed to stir at room temperature for 5 hours. The tetrahydrofuran is evaporated in vacuo, and the residue dissolved in ethyl acetate and washed with water. The ethyl acetate layer is dried over sodium sulfate and evaporated in vacuo to yield present title product.

Provenance & Evidence