HuagongsheHuagongshe Chemistry Print Report · For research reference only
Gamma-Butyrolactone → 4-(4-Methoxyphenoxy)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Gamma-Butyrolactone | HCID 7302 | — |
| Reactant | 4-Methoxyphenol | HCID 9015 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Methoxyphenoxy)butanoic acid | HCID 249649 | — |
Reaction Conditions
| Temperature | 155 °C |
|---|
Reaction Steps
4-Methoxyphenol was added to a solution of NaOC2H5 made by dissolving 2.3 g of Na in 50 ml ethanol. After 5 minutes, gamma-butyrolactone was added and the mixture heated at reflux overnight. Ethanol was distilled off and the residue heated at 155° C. overnight, then cooled, diluted with water and acidified to pH 3 with dilute hydrochloric acid. The product was collected by filtration, 19.5 g, m.p. 103-104° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06166031 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-ed0df414bdb24df0900519926e67e8db |
| Source note | uspto-grants-2000_12 |