2-(2-Chloroethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxyethyl)-3-methyl-3-methylthio-1,3-dihydro-2H-indol-2-one

HRID 1276318Notes

Reaction equation

HRID 1276318 reaction equation
[CH3:1][C:2]1([S:12][CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].Cl[CH2:15][CH2:16][O:17]C1CCCCO1.CC1(C)C2C(=CC=CC=2)N(CCO)C1=O>>[OH:17][CH2:16][CH2:15][N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([CH3:1])([S:12][CH3:13])[C:3]1=[O:11]

Participants

4

Reactant 3

HCID 2549512-(2-Chloroethoxy)tetrahydro-2H-pyranHCID 3266193-methyl-3-methylthio-1,3-dihydro-2H-indol-2-oneHCID 158173642-((3,3-Dimethyl)oxindolyl)ethanol

Product 1

HCID 158173761-(2-Hydroxyethyl)-3-methyl-3-methylthio-1,3-dihydro-2H-indol-2-one

Procedure

Prepared from 3-methyl-3-methylthioindol-2(3H)-one and 2-(2-chloroethoxy)tetrahydro-2H-pyran as described for 3,3-dimethyl-1-(2-hydroxy-1-ethyl)-1,3-dihydro-2H-indol-2-one.

Sources & evidence

ORD record
ord-f565c09a221e4340a72a95d4dbac1786
Source dataset
uspto-grants-2000_12
Patent number
US06166040

Reaction notes

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