反应详情

To a solution of N-tetrahydrofurfurylglycine tert-butyl ester (6.6 g, 0.0307 mol) and 3-acetylthio-2-methylpropionic acid (5.3 g, 0.0327 mol) in dry methylene chloride (150 ml) chilled in an ice bath was added dicyclohexylcarbodiimide (6.7 g, 0.0325 mol). The resulting mixture was stirred with cooling for 30 minutes and then overnight at room temperature. Precipitated dicyclohexylurea was filtered and washed with a small amount of methylene chloride. Concentration of the filtrate afforded crude product as a thick yellow oil which was used without further purification.

1. temperaturewith cooling for 30 minutes
2. customovernight
3. customat room temperature
4. filtrationPrecipitated dicyclohexylurea was filtered
5. washwashed with a small amount of methylene chloride
6. customConcentration of the filtrate afforded crude product as a thick yellow oil which
7. customwas used without further purification