反应详情

3,3-Dimethyl-1-{2-[4-(7-fluoroindol-3-yl)-1,2,5,6-tetrahydro-1-pyridyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one (0.6 g, 1.36 mmol) dissolved in ethanol (40 mls) and acetic acid (4 mls) was added to 10% platinum oxide/charcoal. Hydrogen was admitted for 12 h at 60 psi the catalyst was then removed by filtration, the catalyst washed with ethanol (3×75 mls), concentrated in vacuo and the resulting oil purified by column chromatography on silica with ethyl acetate/Hexane. The fractions containing product were collected and the solvent evaporated in vacuo to give a solid which was converted to the hydrochloride, which was subsequently dried in vacuo to give a solid, mp 172-174° C.

1. customthe catalyst was then removed by filtration
2. washthe catalyst washed with ethanol (3×75 mls)
3. concentrationconcentrated in vacuo
4. customthe resulting oil purified by column chromatography on silica with ethyl acetate/Hexane
5. additionThe fractions containing product
6. customwere collected
7. customthe solvent evaporated in vacuo
8. customto give a solid which
9. customwas subsequently dried in vacuo
10. customto give a solid, mp 172-174° C.