3-Benzyloxazolidine → HCID 13145812, compound

Participants

Reaction Steps

20.0 g of trans-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofurane and 20.0 g of 3-benyl-1,3-oxazolidine are held in 200 ml of absolute ethanol for 48 hours at 70° C. and subsequently solvent and excess 3-benzyl-1,3-oxazolidine are removed, finally in vacuum. After purification by means of a chromatographic column there is obtained 17.2 g of N-(5-(trans-2,3-dihydro-7-methoxy-3-methyl-5-(E)-propenyl-benzofuran-2-yl)-2-hydroxy-3-methoxy-phenylmethyl)-N-(2-hydroxyethyl)-N-benzylamine, a colourless oil, which solidifies in the manner of glass at oil pump vacuum.

Provenance & Evidence