Water → HCID 9949854, compound

Participants

Reaction Steps

This compound is prepared from 2-amino-4-chloro-6-[2-(pyridin-2-yl)ethyl]phenol and 2-thienyl chloride using method A, with ethyl acetate as solvent to give the crude amide in 99% yield. This is treated with methanesulphonic acid in toluene at reflux, with azeotropic removal of water to give the title compound, (31%) as a white crystalline solid after trituration and recrystallisation (EtOAc), m.p. 90-91° C. TLC (SiO2 ; EtOAc:hexanes 1:1, Rf=0.46). Mass Spectrum CI (methane), m/z=341 [M+H]+.

Provenance & Evidence