(-)-Licarin A → HCID 86737595, compound

Participants

Reaction Steps

20.0 g of trans-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofuran and 32.8 g of 2-(3-chlorophenyl)-3-benzyl-1,3-oxazolidine are held in 260 ml of absolute alcohol for 60 hours at 70° C. and subsequently the solvent and excess of 2-(3-chlorophenyl)-3-benzyl-1,3-oxazolidine are removed, finally in vacuum. After purification by means of a chromatographic column there is obtained 9.8 g of N-(5-(trans-2,3-dihydro-7-methoxy-3-methyl-5-(E)-propenyl-benzofuran-2-yl)-2-hydroxy-3-methoxyphenyl-(3-chlorophenyl)-methyl)-N-(2-hydroxyethyl)-N-benzylamin, a bright yellow oil.

Provenance & Evidence