HCID 53917917, compound → HCID 54546026, compound

Participants

Reaction Steps

A solution of (S)-1-(tert-butoxycarbonylamino)-3-cyanopyrrolidine (13.5g, 67 mmol) in 50 mL of 3% NH4OH/methanol and Raney Nickel (0.5 g, 50% slurry in water) was pressurized to 40 psi under H2 atmosphere. After stirring for 12 h at room temperature, the reaction mixture was filtered through a pad of Celite and the residue was washed with 100 mL of methanol. The filtrate was concentrated to dryness to give an oil (S)-1-(tert-butoxycarbonylamino)-3-aminomethylpyrrolidine (10 g).

Provenance & Evidence