Ammonia → HCID 22115309, compound

Participants

Reaction Steps

Neat 3,4-dichlorobenzylamine (18 g, 114 mmol) was added to a solution of dimethyl itaconate (20 g, 114 mmol) in methanol (200 mL) at room temperature. The solution was stirred at for 48 h then concentrated in vacuo. The resulting solid was divided equally into two, one portion being treated with methanolic ammonia (7 M, 300 mL, 2.1 mol). The solution was vented with a needle and allowed to stand for 2 days. The slurry of solvent and product was concentrated further and filtered. The filter cake was washed with cold methanol to give pure 3-aminocarbonyl-1-(3,4-dichlorobenzyl)-pyrrolidin-2-one (18.5 g).

Provenance & Evidence