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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1276372Generated: October 30, 2026

Benzo-1,3-dioxole-5-acetic acid → N-[1-(3,4-methylenedioxybenzyl)pyrrolidin-3-(RS)-ylmethyl]-2-(3,4-methylenedioxyphenyl)acetamide

https://huagongshe.com/reaction/1276372

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reactant3-Aminomethyl-1-(3,4-dichlorobenzyl)pyrrolidineHCID 22115310—
Reactant3-Aminomethyl-1-(3,4-methylenedioxybenzyl)pyrrolidineHCID 22115337—
ProductN-[1-(3,4-methylenedioxybenzyl)pyrrolidin-3-(RS)-ylmethyl]-2-(3,4-methylenedioxyphenyl)acetamideHCID 9865509—

Reaction Steps

Proceeding as described above but substituting 4-(2,5-dimethylphenyl)-4-oxobutyric acid with 2-(3,4-methylenedioxyphenyl)acetic acid and 3-aminomethyl-1-(3,4-dichlorobenzyl)pyrrolidine with 3-aminomethyl-1-(3,4-methylenedioxybenzyl)pyrrolidine gave N-[1-(3,4-methylenedioxybenzyl)pyrrolidin-3-(RS)-ylmethyl]-2-(3,4-methylenedioxyphenyl)acetamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06166015
Source datasetuspto-grants-2000_12
ORD IDord-073b5e6039df4c24a8f6c15f87ae8c33
Source noteuspto-grants-2000_12