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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1276376Generated: October 31, 2026

m-Tolyl isocyanate → 1-[1-(3,4-dichlorobenzyl)pyrrolidin-3-(RS)-ylmethyl]-3-[1-(naphth-1-yl)ethyl]urea

https://huagongshe.com/reaction/1276376

Reaction equation

Participants

RoleNameHCIDCharge
Reactantm-Tolyl isocyanateHCID 69303—
Reactant1-(1-Isocyanatoethyl)naphthaleneHCID 602753—
Reactant3-Aminomethyl-1-(3,4-dichlorobenzyl)pyrrolidineHCID 22115310—
Product1-[1-(3,4-dichlorobenzyl)pyrrolidin-3-(RS)-ylmethyl]-3-[1-(naphth-1-yl)ethyl]ureaHCID 9955679—

Reaction Steps

Proceeding as described above but substituting 3-(RS)-aminomethyl-1-(3,4-methylenedioxybenzyl)pyrrolidine with 3-aminomethyl-1-(3,4-dichlorobenzyl)-pyrrolidine and 3-methylphenylisocyanate with 1-(naphth-1-yl)ethylisocyanate gave 1-[1-(3,4-dichlorobenzyl)pyrrolidin-3-(RS)-ylmethyl]-3-[1-(naphth-1-yl)ethyl]urea.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06166015
Source datasetuspto-grants-2000_12
ORD IDord-5a0daf6b2618497aacc59e31984ced50
Source noteuspto-grants-2000_12