Benzylamine → HCID 15479332, compound

Participants

Reaction Steps

To a stirred solution of [2-ethoxy-3,4-dioxo-cyclobut-1-enyl]-L-phenylalanine methyl ester (0.33 mmol, 100 mg) in absolute ethanol (3 mL) was added neat benzylamine (0.36 mmol, 39 mg; 40 μL) dropwise at room temperature. The resulting solution was stirred at room temperature overnight, during which a white solid precipitated out of solution. The volatiles were removed in vacuo and the residue was taken up in EtOAc and partitioned between EtOAc and water. The organics were dried (Na2SO4), concentrated in vacuo and purified by flash chromatography (SiO2 :EtOAc/hexane) to afford the title compound as a white solid (113 mg; 94%).

Provenance & Evidence