Lithium Hydroxide → HCID 9884766, compound

Participants

Reaction Steps

To a stirred solution of [2-(benzylamino)-3,4-dioxo-cyclobut-1-enyl]-L-phenylalanine methyl ester (0.16 mmol, 60 mg) in THF (5 mL) was added aqueous LiOH (1.0 M; 0.16 mmol; 160 μL) and the resulting solution was stirred at room temperature for 3 hours. The volatiles were removed in vacuo and the residue partitoned between 0.1M acetic acid and EtOAc. The organics were dried (Na2SO4) and concentrated in vacuo to afford the title compound as a white solid, mp=215-216° C. (33 mg; 59%).

Provenance & Evidence