HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetoxyacetyl chloride → (S)-(-)-N-[[2-oxo-3-[3-fluoro-4-[1-[(acetoxy)acetyl]-3,6-dihydro-2H-pyridin-4-yl]phenyl]-5-oxazolidinyl]methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetoxyacetyl chloride | HCID 26297 | — |
| Reactant | Benzyloxyacetyl chloride | HCID 177085 | — |
| Reactant | (S)-(-)-N-[[2-Oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide | HCID 11559039 | — |
| Reactant | [2-Oxo-3-[4-(4-piperidinyl)phenyl]-5-oxazolidinyl]methyl acetamide | HCID 86756146 | — |
| Product | (S)-(-)-N-[[2-oxo-3-[3-fluoro-4-[1-[(acetoxy)acetyl]-3,6-dihydro-2H-pyridin-4-yl]phenyl]-5-oxazolidinyl]methyl]acetamide | HCID 18684835 | — |
Reaction Steps
Following the general procedure of EXAMPLE 18, and making non-critical variations but substituting (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyllmethyl]acetamide (EXAMPLE 38) for (S)-(-)-N-[[2-oxo-3-[4-(4-piperidinyl)phenyl]-5-oxazolidinyl]methyl acetamide and acetoxyacetyl chloride for benzyloxyacetyl chloride, the title compound is obtained, mp 188-191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06166056 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-6c627cdb15954e55890c34cf5e2ce003 |
| Source note | uspto-grants-2000_12 |