HCID 18428365, compound → HCID 11163443, compound

Participants

Reaction Steps

n-BuLi (0.192 ml, 0.48 mmol) was added to a solution of 4-(2,2-dibromovinyl)-1-(triphenylmethyl)imidazole (108 mg, 0.22 mmol) in THF (5 ml) at -78° C. under N2. The reaction mixture was quenched by the addition of saturated ammonium chloride (50 ml) and extracted with ethyl acetate (75 ml). The ethyl acetate layer was washed with water (50 ml), separated, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by flash chromatography gave 2[1-triphenylmethyl-1H-imidazol-4yl]ethyne, which was deprotected with 2N HCL to give 18 mg of final product. ##STR77## 4-Ethynylimidazole (46) 1H-NMR (300 MHz, CD3OD): δ8.94 (s, 1H), 7.80 (s, 1H), 4.20 (s,1H); Mass Spectrum (Cl) m/e 93 (M+1).

Provenance & Evidence