4-Phenylazepane → HCID 54191975, compound

Participants

Reaction Steps

The title compound was prepared from 20 mg of 1-Benzyl-3-(SR)-formyl-4-(SR)-phenylpyrrolidine, 13 mg of 4-phenyl-perhydro-azepine and 25 mg of sodium triacetoxyborohydride using a procedure analogous to that described in Example 9, Step B to provide 18.5 mg of the title compound. RF : 0.37 (50% EtOAc in hexanes). 1H NMR (300 MHz, CDCl3): δ1.48-1.83 (m, 6H), 2.37-2.69 (m, 10H), 2.88-3.01 (m, 3H), 3.67 (ABq, J=13 Hz, 2H), 7.09-7.39 (m, 15H). Mass Spectrum (CI): 425.3 (M+H).

Provenance & Evidence