Ethyl 4-piperidinecarboxylate → HCID 70200252, compound

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Reaction Steps

The title compound was prepared from 400 mg of 1-Benzyl-3-(SR)-formyl-4-(SR)-phenylpyrrolidine, 0.24 mL of ethyl isonipecotate and 480 mg of sodium triacetoxyborohydride using a procedure analogous to that described in Example 9, Step B to provide 363 mg of the title compound. RF : 0.31 (50% EtOAc in hexanes). 1H NMR (300 MHz, CDCl3): δ1.22 (t, J=7.1 Hz, 3H), 1.54-1.89 (m, 6H), 2.13-2.21 (m, 1H ), 2.33-2.64 (m, 6H), 2.77-2.97 (m, 4H), 3.65 (ABq, J=13 Hz, 2H), 4.09 (q, J=7.1 Hz, 2H), 7.14-7.37 (m, 10H). Mass Spectrum (CI): 407.3 (M+H).

Provenance & Evidence