Potassium Permanganate → 2-Fluoro-4-methoxybenzoic acid

HRID 1276516Notes

Reaction equation

[O-:1][Mn](=O)(=O)=O.[K+].C[C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][C:11]=1[F:18])=[O:9]>>[F:18][C:11]1[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:10]=1[C:8]([OH:9])=[O:1]

Participants

Reactant 2

HCID 516875Potassium Permanganate

HCID 5928212'-Fluoro-4'-methoxyacetophenone

Product 1

HCID 27745422-Fluoro-4-methoxybenzoic acid

Procedure

2-Fluoro-4-methoxybenzoic acid was synthesized by KMnO4 oxidation of 2-fluoro-4-methoxyacetophenone (Clarke, H. T.; Taylor, E. R., Org. Synth. Coll. Vol II, 135-136).

Sources & evidence

ORD record: ord-692cb9c65b4740bbb079a26a4d4e4b9b
Source dataset: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06166072

Reaction notes

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