HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoroindole → 5-Fluoroindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoroindole | HCID 67861 | — |
| Catalyst | ZINC;boranuide | HCID 12838295 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-Fluoroindoline | HCID 2774463 | 102.1% |
Reaction Steps
A solution of 6.8 grams (0.05 moles) of 5-fluoro-1H-indole in 50 ml of ether was cooled to 0° C. under nitrogen. 507 ml of a 0.15M solution of zinc borohydride in ether was added dropwise. The reaction was allowed to stir for 48 hours. The reaction was quenched with dilute hydrochloric acid. The pH was adjusted to 8.0 with dilute sodium hydroxide. The ether layer was separated, dried and evaporated to give 7 grams of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06166064 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-b712509d9ac64bd5a964a0e69ed7d6c3 |
| Source note | uspto-grants-2000_12 |