HCID 54280196, compound → HCID 54455803, compound

HRID 1276531Notes

Reaction equation

HRID 1276531 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[S:11]([NH2:14])(=[O:13])=[O:12])[NH:7][CH2:6][CH2:5]2>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[S:11]([NH2:14])(=[O:13])=[O:12])[NH:7][CH:6]=[CH:5]2

Participants

3

Reactant 1

HCID 54280196HCID 54280196, compound

Product 1

HCID 54455803HCID 54455803, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3 grams of mangenese dioxide and 3 grams of 5-fluoro-2,3-dihydro-1H-indole-6-sulfonic acid amide in 30 ml of dioxane was heated at 50° overnight. The reaction was filtered and the filtrate was evaporated to afford crude product which was purified on silica gel eluting with methylene chloride/ethyl acetate to give 1.1 grams of the titled compound. mp: 181-182° C.

Workup

  1. temperaturewas heated at 50° overnight
  2. filtrationThe reaction was filtered
  3. customthe filtrate was evaporated
  4. customto afford crude product which
  5. customwas purified on silica gel eluting with methylene chloride/ethyl acetate

Sources & evidence

ORD record
ord-c258d18653e146e98dd81b394c7337e5
Source dataset
uspto-grants-2000_12
Patent number
US06166064

Reaction notes

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