HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-[3-[[[(4-Chloro-2,6-diisopropylphenylamino)carbonyl]amino]sulfonyl]-5-acetylphenyl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-Chloro-2-isocyanato-1,3-di(propan-2-yl)benzene | HCID 15479960 | — |
| Reactant | 3,5-Diacetylbenzenesulfonamide | HCID 18461608 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[3-[[[(4-Chloro-2,6-diisopropylphenylamino)carbonyl]amino]sulfonyl]-5-acetylphenyl]ethan-1-one | HCID 22116283 | 40.3% |
Reaction Steps
The title compound was prepared as described in method A from 3,5-diacetylbenzenesulfonamide (0.35 grams). 4-chloro-2,6-diisopropylphenylisocyanate (0.37 grams), sodium hydride (0.06 grams of a 60% dispersion in mineral oil), in tetrahydrofuran (4 mL). This afforded 0.28 grams of the title compound, m.p. 201.9-203.4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06166064 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-9e1690d80eef431d9f1c0324e19820b1 |
| Source note | uspto-grants-2000_12 |